Dr. S. Vincent Rajkumar, Mayo Clinic hematologist, discusses the first systematic study to determine association of Monoclonal Gammopathy of Undetermined Significance (MGUS) with all diseases in 17,398 patients, published in Mayo Clinic Proceedings.
Here is a link to the article: http://www.mayoclinicproceedings.com/…
Click on the following link to hear Dr. Rajkumar talk about this study.



How can I get a written copy of this article “Diseases Associated with MGUS” from the Mayo Clinic Proceedings. I have been diagnosed with MGUS and have multiple other medical problems and am curious about possible relationship between these conditions. I feel it will be a valuble aid for me in asking appropriate questions about my condition when I next see my Hematologist. Thank you!
New Shingles Dx–need to see what else–before waiting another month for recheck of MGUS
Hi,
I was diagnosed with MGUS in early 2010 and know that it is related to Multiple Myeloma and upon the research I have done online – Multiple Myeloma can cause muscle weakness.
I have a problem that I find very limiting and my oncologist is only interested in my blood counts and won’t answer this one very specific question for me.
Can MGUS cause muscle weakness in the legs? I can be walking along finely and then my legs go weak and I have trouble walking and I am scared I am going to fall over – it is so distressing and so embarrassing
A very simple question for an oncologist but I never get an answer – just yearly pathology requests when I see him once a year. Maybe if I had Multiple Myeloma my oncologist may
be more forthcoming with an answer to my question.
I haven’t got Multiple Myeloma at this point in time and I can only pray that my MGUS stays as it is and does not progress to Multiple Myeloma.
Would someone with expertise in MGUS please answer this most pressing question for me please. At this point in time knowledge would help me deal with this quiet distressing weak leg syndrome – if it is part and parcel of MGUS it will put my mind at ease and if there is a medication that will assist this condition could you please advise me so that I may in turn tell my GP about it.
Trusting you can help me with this very pressing question because I do live alone and this weak legs syndrome is something I need to address urgently.
I look forward to hearing from somebody who has the knowledge to address the above issue.
Thank you for your forum.
Sincerely,
Denise Humphries
HI Denise, Unfortunately we are unable to offer medical advice or provide a second opinion without an evaluation. Please contact one of our appointment offices at: http://www.mayoclinic.org/patientinfo/appointments.html
Thank you.